Endocrine Abstracts

ApoB plays a central role in lipoprotein metabolism through regulation of total cholesterol and LDL-cholesterol (LDL-C) concentrations in plasma. Two restriction fragment length polymorphisms (ECoRI and XbaI) represent single base alterations in the coding region of ApoB gene. ECoRI polymorphic region of ApoB gene is due to on an amino acid change (Glu→Lys). The XbaI polymorphic region of ApoB gene results from a substitution of (A→T) in the threonine codon and doe...

Symptomatic hyperparathyroid patients are under risk of increased cardiovascular mortality, associated with left ventricular hypertrophy, diastolic dysfunction and accelerated atherosclerosis. Data on asymptomatic hyperparathyroid patients are conflicting. This study aimed to determine diastolic dysfunction and its association with carotis intima media thickness (CIMT) and flow-mediated vasodilation (FMD) in a group of asymptomatic hyperparathyroid patients.<p class="abste...

Cardiovascular diasease (CV) is the leading cause of mortality in acromegalic patients. Although acromegalic cardiomyopathy has been extensively investigated, there is a lack of data about atherosclerosis in acromegaly.We aimed to the evaluate the extent of carotid atherosclerosis with various CV biomarkers in acromegaly. Sixty-one acromegalic patients and 21 age and sex matched healthy controls were included. We measured carotid intima media thickness (...

Hypothyroidism is associated with increased cardiovascular mortality. Epicardial fat thickness (EFT) has been found to be correlated with visceral fat accumulation and is thought to be a novel cardiovascular risk factor. The aim of this study was to determine EFT and its relationship with carotid intima media thickness (CIMT) and flow-mediated vasodilation (FMD) in subclinical and overt hypothyroid patients.Ten patients with overt (Group H) (42.2±15...